Increased collagen degradation around loosened total hip replacement implants

BMPs in periprosthetic tissues around aseptically loosened total hip implants

BACKGROUND AND PURPOSE Primary and dynamically maintained periprosthetic bone formation is essential for osseointegration of hip implants to host bone. Bone morphogenetic proteins (BMPs) play a role in osteoinductive bone formation. We hypothesized that there is an increased local synthesis of BMPs in the synovial membrane-like interface around aseptically loosened total hip replacement (THR) i...

Total hip replacement (THR).

The authors present history, indications and complications of total hip replacement in 206 patients in a period of 10 months. They compare the rate of complications with published data. They present pre-operative examination, prophylaxis and specific problems in their conditions.

Total hip replacement.

Dislocation following total hip replacement.

An analysis of 142 dislocations from a multicentre study of 6774 total hip replacements is reported. The incidence of dislocation was 2.1 per cent. Patients with neuromuscular disorder, those in a confused mental state, and those undergoing revision operations are at special risk. The commonest surgical error, present in nearly half the patients, was placing the acetabular cup too vertically or...

Which primary total hip replacement?

To assist surgeons to select a total hip replacement (THR) we present comparative information on all such implants on the market in the UK. We identified 62 different primary THRs, manufactured by 19 companies; half had been introduced in the last five years, and only 30% have any results published in peer-reviewed journals. The prices range from 250 pounds to 2000 pounds, and the two cheapest ...